Molecular Identification of Antigen Recognition Structures in Immune Complexes for Immunotherapeutic Applications by Proteolytic and Mass Spectrometric Methods

It is not the possession of truth, but the success which attends the seeking after it, that enriches the seeker and brings happiness to him. Paraschiv and Ute Schad for all the help they gave me, Reinhold Weber for the organization and expert group leading in the Swiss Alps. Livia and Ioana for their support and the wonderful time spent together. Last but not least I wish to thank and to express my deep gratitude to my family, for supporting and encouraging me during this time. (2004) " Zinc binding agonist effect on the recognition of the ß-amyloid (4-10) epitope by anti-ß-amyloid antibodies " , Biochem. Biophys. Res. (2005) " Implications of the serine protease HtrA1 in amyloid precursor protein processing " , Proc. Natl. Acad. "Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high resolution mass spectrometry", Eur. Przybylski M. (2005) " Epitope extraction technique using a proteolytic magnetic reactor combined with Fourier-transform ion cyclotron resonance mass spectrometry as a tool for the screening of potential vaccine lead peptides " , Eur. J. approaches for elucidation of antigen-antibody recognition structures in molecular immunology " , Eur. Przybylski M., (2003) " Mass spectrometric and immunoanalytical characterisation of an amyloid plaque-specific epitope of a therapeutically active anti-Aß42 resolution mass spectrometric cleavage site elucidation of the novel serine protease HtrA involved in amyloid precursor protein processing " , Human Proteome Organisation (HUPO) 4 spectrometric and immunoanalytical epitope characterisation of a specific antibody to the H1-carbohydrate recognition domain of the asialoglycoprotein receptor " , 17 th